The following brief article in The Boston Globe, July 8, 2011 discusses a recent study which looked at the relationship between macular degeneration and genetics. Cigarette smoking was also strongly connected to the incidence of advance macular degeneration.
We’ve known for years that macular degeneration – the leading cause of blindness in people over 55 – is associated with genetic as well as environmental factors. But how can we tease the two apart? Researchers at Tufts Medical Center found one way to do so: Study twins.
A study published last week in the journal Opthalmology looked at over 200 male pairs of identical twins. In some of the pairs, each twin had age related macular degeneration (AMD), but at different stages, while in other pairs only one twin had the disease. Based on questionnaires filled out by participants, as well as their AMD diagnoses, the study found that the twin with the more advanced stage of AMD tended to be a heavier smoker. And, twins in whom AMD progressed more slowly reported higher intakes of the nutrients betaine and methionine. Foods like fish, grains, and spinach have betaine, while methionine is found in poultry, fish, and dairy products.
So what does this mean for your susceptibility to AMD? “There’s definitely a strong genetic component,” says the study’s lead author, Dr. Johanna M. Seddon. A previous study of identical and fraternal twins done by her research team found that genetics explained between 46 and 71 percent of the severity of the disease, while environmental factors explained between 19 and 37 percent. But that doesn’t mean that there’s nothing you can do about it.
“One of the modes of management of this disease is adherence to healthy diet,” said Seddon, a professor of ophthalmology at Tufts University School of Medicine and an ophthalmologist at Tufts Medical Center. “This study underscores the fact that, here you are with twins with the same genes, and there’s no question that these behavioral modifiable factors make a difference.”
Protecting your eyes from the sun is another way to guard against AMD, as we wrote about last week.
Contact Neena Satija at nsatija@globe.com.